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Full gene-replacement model developed for Alzheimer’s MAPT gene research
Researchers in the US have successfully produced a mouse model with a human MAPT gene to enable more accurate research into Alzheimer’s therapy.
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Three-dimensional structure of the genome replication machine discovered
New research provides insights into how cancers can arise when DNA polymerase delta is not functioning properly.
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Scientists discover unique imaging technique to view synapse proteins
Researchers in the US have devised a new way to clearly image proteins located in synapses, which they hope will faciliate future treatment for diseases associated with blocked gene expression.
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Researchers find DNA therapy could treat patients with DMD
A study has revealed that using DNA-like molecules to repair gene mutations in models could act as a successful therapy for patients.
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The elegant parallel of using CRISPR to understand disease mechanisms
CRISPR is the buzzword of the moment in the drug discovery industry – mainly due to its potential to correct disease-causing mutations. However, those using the technology need to be mindful that it is used responsibly, and possible risks are considered before use. Mark Behlke discusses the potential of CRISPR…
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eBook: Explore pathways like a pro
Scientists studying particular disease states often search cellular signaling pathways to gain insight into DNA, RNA, and protein function.
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Whitepaper: Evaluating the impact of error rate on productivity and cost savings in synthetic DNA fragments
GeneArt High-Q Strings DNA Fragments versus other suppliers’ products.
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Application note: Faster and more reliable quantification of oligonucleotide interaction with human serum albumin using MST
Antisense oligonucleotides are an emerging therapeutic option for treating diseases with known genetic origin.
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Expert view: The importance of accurate synthetic DNA fragments
Innovations in synthesis technology and gene synthesis have become a powerful and valuable means of obtaining genetic material.
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Upstream Bioprocessing In-Depth Focus 2019
This In-Depth Focus features articles highlighting the importance of effective data management strategies as well as the recent trends in upstream bioprocessing.
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Five recent Parkinson’s disease drug target discoveries
This article highlights five of the latest findings that could be used in the development or design of new therapies to treat Parkinson’s disease.
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Researchers identify key mechanism of typhoid toxin
The process of Salmonella typhi to damage DNA has been revealed by researchers at the University of Sheffield which could inform treatments.
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Researchers develop new DNA microscopy technique
The novel method for imaging molecules in cells and tissue samples, called DNA microscopy, could improve knowledge of disease development.
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Uncharted area of genome mapped by advanced imaging
Researchers have mapped a previously uncharted region of the human genome which could lead to tests for certain conditions in the future.
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Telomere damage in cells is caused by runaway mitochondria
Using new technology researchers have shown that sick mitochondria pollute the cells they are supposed to be supplying with power.
