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Relationships between SLCs and cytotoxic drugs in human cells uncovered
A new systematic investigation on the role of solute carriers could lead to further insights into how the transporters affect the uptake and activity of drugs.
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Drug Delivery
Drug delivery refers to approaches for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect.
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Exploring future spinal cord injury therapies
Drug Target Review explores five of the latest research developments in the field of spinal cord injury (SCI) repair.
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Scientists can now ‘listen in’ on cancer cells with new technique
More effective drugs could be developed due to a new technique that has allowed scientists to decipher how millions of individual cells are communicating with each other on miniature tumours grown in a lab.
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Protein injections in medicine could one day be possible, says new study
A new study could lead to medical compounds one day being introduced into cells with the help of bacterial toxin and could open up new possibilities in cancer medicine.
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Researchers develop vaccine with potential to treat pancreatic cancer
A study has demonstrated that a novel vaccine design for pancreatic cancer has been successful in mice, doubling survival time.
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How will CRISPR evolve in the future?
CRISPR is a tool used by researchers to precisely edit genes and has shown potential for treating genetic diseases. This article delves into some recent developments and explores what the future holds for CRISPR.
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A faster and stronger rabies vaccine has been developed
A new rabies vaccine strategy enhanced the speed and magnitude of the anti-rabies antibody responses and could improve the efficacy of currently used vaccines.
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Short peptides discovery could lead to new treatments for Alzheimer’s
The memory of mice with Alzheimer's greatly improved after they were injected with two newly discovered short peptides.
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Researchers improve CRISPR-Cas9 delivery efficiency
A team has used a lentiviral capsid-based bionanoparticle system to deliver CRISPR-Cas9 gene editing therapies, reducing undesired effects.
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Treatment for polycystic kidney disease shows promising results
A potential treatment for polycystic kidney disease has shown positive results in animal testing.
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Drug Target Review – Issue 3 2019
This issue includes an investigation into utilising recombinant antibodies for research, a highlight on protein design using computational methods and an examination of the advances in genomic medicine. Also in the issue are articles on next generation sequencing and upstream bioprocessing.
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High-content imaging: challenges of the 3D world
The potential of three-dimensional cell culture models is now well-recognised by scientists; however, there are still some challenges. Margaritha Mysior and Jeremy Simpson address some of the common challenges of working with spheroids and organoid models – including how they are developed and how to obtain high-resolution, high-content images and…
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New method could speed up drug development and diminish drug trial fails
A new method of assessing the actions of medicines by matching them to their unique protein receptors could accelerate drug development.
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Transforming drug discovery, development and delivery with flow chemistry
Flow chemistry is on the rise thanks to the commercial availability of benchtop continuous flow systems that has driven widespread adoption of the technique across a broad range of applications in both academia and industry. In particular, flow chemistry is delivering significant benefits in the area of drug discovery and…
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Calcium carbonate sprayable gel could fight cancer
A sprayable gel containing calcium carbonate nanoparticles with an antibody specifically targeted to block CD47, could be the future of cancer treatments...
