List view / Grid view
The future of drug discovery lies in an automated world where the workflows for biological assays, chemical synthesis and data analysis are connected by flexible, mobile and modular hardware, integrated with software solutions that will interface with scientists for increased efficiency and productivity (the realisation of Industry 4.0). This article…
Researchers have used high-throughput screening on AAV vector capsid libraries to identify which ones are best for certain gene therapies.
The National Drug Discovery Centre (NDDC) has opened in Australia, with support from the government to subsidise the screening of medicinal compounds.
A collapsible basket technology has been developed to significantly accelerate the analysis process when scientists are developing new medicines.
Researchers have screened 20,000 molecules to discover a potent compound with low toxicity that restores the balance of healthy stem cells in the lungs of mice.
A new method has been developed by researchers to create synthetic molecules which replicate natural structures and have potential medicinal uses.
A high-throughput screening test of different cannabinoids has demonstrated that CBC and CBG exhibit anti-tumour effects.
This issue includes a discussion on the future of high-throughput screening through collaboration, an analysis of mass spectrometry as a structural biology tool and an exploration of the challenges of hit-to-lead when researching tropical diseases. Also in the issue are articles on immuno-oncology and assays.
Researchers have created a new high-throughput screening system which could identify new drugs by focusing on nucleotide metabolism.
A pioneering team of scientists from Rice University has discovered that a particular combination of chemotherapeutics, including mitocans that target mitochondria, form a powerful treatment for acute myeloid leukaemia patients.
A machine-learning algorithm has been created that automates high-throughput screens of epigenetic medicines.
A world-first compound that can keep cells alive and functioning in a healthy state could be revolutionary for medical emergencies.
A study that identified 12 novel compounds that may prove valuable against new drug targets for leishmaniasis and Chagas disease was not without complication. Here, we discuss the findings but also the challenges the researchers reported in their hit-to-lead study.
Researchers have used a high-throughput screening method to test over 125,000 molecules and identify a new class of antibiotics.
A study using high-throughput screening has revealed some promising compounds that could be used in future cancer treatments.
