Expert view: Promising methods in kinase screening
Kinase-mediated phosphorylation is a control point for nearly all activity within a cell, making kinases important in many diseases.
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Kinase-mediated phosphorylation is a control point for nearly all activity within a cell, making kinases important in many diseases.
A new study has shown that restoring the amount of the kinase, HIPK2, in a kinase-depleted mouse model rescued it from heart failure and identifies HIPK2 as a novel regulator of heart failure progression.
A novel CDK8 inhibitor has been developed by scientists at Ryvu Therapeutics. Dr Krzysztof Brzozka showcases this molecule and explains the R&D behind it.
A research team has found that blocking a particular kinase in a mouse model of arrhythmogenic cardiomyopathy led to improved survival rates.
Researchers have found that inhibiting a kinase in mice leads to the death of prostate cancer cells, providing a potential therapeutic target.
Salk scientists discover a pair of enzymes that drive non-small-cell lung cancer by promoting inflammation which could inform the development of new therapies.
New research has identified an enzyme which causes degradation of dendritic spines, pointing to a drug target for Alzheimer’s.
This application note discusses how the ADP-Glo™ Kinase assay is a universal, homogeneous, high-throughput screening method that measures kinase activity by quantifying the amount of ADP produced during the kinase reaction.
Breakthrough research has uncovered an unexpected mechanism that underlies cardiomyopathy in DMD...
Researchers in Spain have identified a means of classifying patients with the most aggressive form of breast cancer - triple negative breast cancer; providing meaningful prognosis for the first time.
Physiologically relevant screening models have become increasingly important in assay development and the screening of drug candidates.
A study has shown how the elimination of the c-Raf kinase by genetic manipulation causes the regression of Kras oncogene-driven advanced lung tumours...
A study has identified the genes involved in the latent asymptomatic state of breast cancer metastases...
Scientists have successfully blocked the powerful call of two types of aggressive cancer – glioblastoma and breast cancer – in laboratory models; with evidence that inhibiting the chemical 20-HETE halts tumour growth.
A team of researchers from the University of Liverpool and AstraZeneca has made an important contribution to our understanding of cancer cell regulation, holding promise for improved future cancer treatment.