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Study identifies key regulator of cell differentiation
Long-awaited findings about cell differentiation will be relevant in understanding normal development and may also be useful in cancer research.
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Molecular Targets
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New cryo-EM method reveals insight into blood disorders
A molecular cage, developed for use during cryo-EM, has provided researchers with new insights into a key cancer protein.
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Promising target for osteoporosis treatments found in new study
By identifying a mechanism behind bone strengthening in response to stress, researchers have found a possible new target for treating conditions that weaken bones.
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Study identifies new therapeutic target for haematologic malignancies
Using chemical genetic screening and pre-clinical model studies, researchers have discovered that inducing ubiquitin-mediated degradation of mutant EZH2 could provide a more effective treatment strategy for haematologic malignancies.
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Pathway to treat type 1 diabetes revealed in study
A new study has identified harmful cellular pathways that prevent insulin production, presenting a drug target for diabetes.
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Novel CAR T-cell therapy for B-cell cancers shows promise in vivo
A new CAR T-cell therapy for B-cell cancers promises to reduce the antigen escape currently found in therapies that only target CD19.
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New research sheds light on what influences target protein binding time
The length of time that drug molecules attach to their target protein varies greatly and impacts the protein’s behaviour and drug efficacy. In a new study, scientists in Finland have identified some causal factors for this variance, with the hope it will bring clarity for drug developers.
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New protein that enables SARS-CoV-2 access into cells identified
Researchers have found that extracellular vimentin facilitates SARS-CoV-2 entry into human cells, presenting a new target.
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Gut-brain pathway metabolite involved in age-related cognitive decline, study shows
In mice, researchers have shown that δ-valerobetaine plays a role in neurocognitive ability, making the metabolite a target for age-related memory loss.
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Bristol Myers Squibb research reveals atomic structure of protein receptor CD47
New Bristol Myers Squibb research has revealed details about the structure of the protein receptor CD47, which helps protect cells from the human immune system.
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CRISPR activation screening: finding genes that interact with SARS-CoV-2
Dr Greg Neely, University of Sydney, explains how he and his team used pooled whole genome CRISPR activation screening to identify LRRC15 as a SARS-CoV-2 spike-interacting protein.
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Opportune identification of novel multiple myeloma target
During investigations into the tropical disease Buruli ulcer, researchers have instead identified a promising new avenue for potential treatments for multiple myeloma.
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Novel method for chemo capture – up to three times more effective
A team of researchers in the US has devised a new means of removing excess chemotherapy drugs from a patient’s bloodstream, with potential for wider clinical and materials science applications.
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CRISPR screens and novel drug targets
According to a new study, a metabolic enzyme studied in cancer biology is key for T-cell function, offering a novel target for anti-inflammatory therapeutics. Dr Jeffrey Rathmell and Ayaka Sugiura from Vanderbilt University in the US discuss their study with Drug Target Review and why inhibiting or genetically deleting the…
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Treating cancer patients with cancer anorexia-cachexia syndrome
In this article, Patrick Kendall, Scientific Advisor for Artelo Biosciences, outlines why future treatment of cancer anorexia-cachexia syndrome may lie with drugs in development offering a mechanistic approach.
