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Targeting SARM1 to protect vision across retinal degenerative diseases
Dr Sarah Doyle and Dr Ema Ozaki outline their research into SARM1 and why it presents an attractive target for treating retinal degeneration.
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Proteomics
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N terminal domain of S protein revealed as antibody target for COVID-19
An antibody with high neutralising potency against SARS-CoV-2 that binds to the N terminal domain of the Spike protein has been identified by a team researching COVID-19 therapeutics.
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New antibody cocktail developed as potential therapy for COVID-19
Researchers have proposed a cocktail of two antibodies which they say could provide an effective therapy for COVID-19 patients.
whitepaper
ebook: The definitive guide to understanding protein stability
Learn how to measure protein stability, why it’s important, and what the key technologies are available to measure it.
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SARS-CoV-2 immunodominant epitopes identified as vaccine candidates
Researchers have analysed the SARS-CoV-2 proteome to reveal seven promising immunodominant epitopes that could aid in the development of a COVID-19 vaccine.
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Video: ESHG 2019 conference discussion panel: automated sample preparation
A result is only as good as the sample preparation that preceded it.
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Video: Overview of the KingFisherTM instruments
ESHG 2019: Automated sample preparation using magnetic bead technology and KingFisher instruments.
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Computational approach identifies novel COVID-19 vaccine targets
Researchers used computational tools to identify regions of the SARS-CoV-2 virus that could potentially provide a safe and long-term immune response.
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Study identifies pathway responsible for blood-brain barrier impairment in Alzheimer’s
The team found that the expression of the APOE4 gene variant in pericytes caused amyloid plaque formation in a blood-brain barrier model.
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Video: Isolate Circulating tumor cells using the KingFisher
New opportunities for liquid biopsy: At automated workflow for isolating circulating tumor cells using KingFisher instruments.
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TiPARP activation should be the target of future cancer drugs, says researcher
Scientists reveal activating tumour suppressor protein TiPARP results in the degradation of several transcription factors implicated in cancer survival.
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Seeing the light – visualising protein translation in real time
Non-invasive imaging has played an increasing role in drug discovery and development processes. Nikki Withers spoke with Yochi Slonim, who discusses a novel technology that leverages FRET signals for the discovery of small molecule drugs that selectively control mRNA translation in a novel target space.
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Delivering a therapy to kerb COVID-19
Sheraz Gul explores current research developments to help treat and tackle the spread of COVID-19.
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The Crick HTS facility – facilitating research through large-scale screening
The high-throughput screening (HTS) facility at the Francis Crick Institute in the UK provides a core service for Crick research groups. It enables scientists to use large-scale, unbiased screening technologies and approaches as part of their research. Nikki Withers spoke to the Science Technology Platform Head, Michael Howell, to hear…
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Neoantigens: presenting new vaccine opportunities in immuno-oncology
Neoantigens have gained much interest in recent years, mainly due to their ability to elicit a strong, specific immune response. Nikki Withers spoke to two immunology experts to explore the progress being made and assess what remains challenging for cancer investigators working on these transformational therapies.
