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Vaccine strategy against chronic inflammatory diseases developed
A study in mice has shown that immunisation against bacterial flagellin could lead to protection from chronic inflammatory diseases.
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Research & Development
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Promising new therapy developed to treat leukaemia
VTP50469, a new targeted therapy for MLL-rearranged leukaemia, shows greater efficacy and fewer side-effects in mice, according to new research.
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Antibodies could be used as nanotechnology builders
Endogenous human antibodies can be used to build and dismantle 2D and 3D DNA nanostructures, finds new research.
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Epigenome editing used to reverse gene mutation in mice
A study has demonstrated the success of changing the genome of mice, regulating the production of the C11orf46 gene.
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Muscle weakness after sepsis linked to mitochondrial dysfunction
Researchers have found that damage to mitochondria due to sepsis may be the cause of muscle weakness in mice.
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T cells could work as therapy for IBD in children, finds study
Researchers have found that a type of T cell, called a Tr1 cell, could work as a therapeutic strategy for inflammatory bowel disease in children.
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Research shows the pharma industry believes AI will likely optimise R&D
A survey has shown that the pharmaceutical industry believes R&D will see a lot of benefit from digital transformation and that AI will be at the forefront.
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Appearance of proteins used to predict function with machine learning
Researchers have used a machine-learning algorithm to study protein appearance and discover common features that influence function, which could be used to design artificial cells.
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Hit-To-Lead In-Depth Focus 2019
This in-depth focus features articles on identifying new leads for neglected tropical diseases and how to develop novel peptide hits into lead compounds.
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Targets In-Depth Focus 2019
The articles in this In-Depth Focus explore a novel technique for studying protein aggregation in Alzheimer's research and explain how to maximise the potential of mass spectrometry.
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Activating bone stem cells has potential therapeutic applications
A study has demonstrated that activating bone periosteal stem cells leads to increased bone healing in mice, presenting a potential therapeutic strategy.
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Screening In-Depth Focus 2019
In this In-Depth Focus are articles investigating how CROs can help to drive innovation and how CRISPR technologies could be used for drug screening purposes.
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Drug Target Review – Issue 4 2019
This issue includes a discussion on the future of high-throughput screening through collaboration, an analysis of mass spectrometry as a structural biology tool and an exploration of the challenges of hit-to-lead when researching tropical diseases. Also in the issue are articles on immuno-oncology and assays.
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New class of drugs with potential to fight leukaemia and lymphoma discovered
PROTAC drugs that safely and effectively target leukaemia and lymphoma cells have been developed by researchers.
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New method to analyse CRISPR editing developed
Researchers have announced the creation of a novel technique for screening CRISPR edits that allows scientists to identify unintended outcomes in the genome.
