List view / Grid view

Screening

 

Medical screening is a strategy used to identify the possible presence of an as-yet-undiagnosed disease in individuals without signs or symptoms.

article

Transcriptional reprogramming rescues vascular fate of misidentified pluripotent cell‑derived epithelial cells

22 June 2021 | By

A team of scientists has found that a type of cell derived from human stem cells and widely used for brain research and drug development may have been leading researchers astray for years. Here, Dr Raphaël Lis from Weill Cornell Medicine explains how forcing the activity of three known endothelial cell transcription…

article

Covalent fragment screening in cell-based phenotypic models of disease: a collaborative approach

22 June 2021 | By , , , ,

The application of chemical perturbation approaches in phenotypic models is often used to identify protein targets for therapeutic discovery. Increasingly, small molecule fragments which covalently bind to their protein targets are being used to explore the druggable proteome and the resulting fragment‑protein interactions are characterised by chemoproteomic techniques. In this…