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Video: Isolate Circulating tumor cells using the KingFisher
New opportunities for liquid biopsy: At automated workflow for isolating circulating tumor cells using KingFisher instruments.
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Screening
Medical screening is a strategy used to identify the possible presence of an as-yet-undiagnosed disease in individuals without signs or symptoms.
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Application note: Sensitive detection of viral nucleic acids
A simple and sensitive method for nucleic acid extraction from virus-containing samples, with a range of viral loads.
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ebook: How FBDD improves hit rates & delivers high-value targets
Learn how fragment-based drug discovery improves hit rates and delivers higher-value targets using various biophysical methods.
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Current state of NAFLD treatments and the promise of in vitro platforms towards better screening of drug candidates
The heterogeneous pathogenesis of metabolic fatty liver diseases presents researchers with numerous challenges when trying to develop a treatment. This article explores the spectrum of these diseases and presents a novel in vitro platform for screening drug candidates.
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Guide: Five ways biophysical tools help brain studies
Learn why researchers turned to biophysical methods to expose the molecular mechanisms of neurodegenerative diseases.
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Researchers identify 27 biomarkers of COVID-19 disease severity
Mass spectrometry revealed biomarkers that could be used as drug targets for developing novel therapeutics or to predict whether a patient with COVID-19 will become severely ill.
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Application note: CRISPR-Cas9 screening for target identification
The identification and validation of novel drug targets is a challenging process for drug discovery programmes.
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Application note: High-throughput sialylation screening in combination with titer monitoring for expediting clone selection in cell-line development
Glycosylation is one of the most important post-translational modifications when developing new biologics. It has a considerable impact on product performance and variability and is therefore a critical quality attribute (CQA), influencing product safety and efficacy.
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Expert view: CRISPR screening: a powerful approach to drug discovery and development
CRISPR screening utilises the power and precision of CRISPR-Cas9 gene editing to reveal and validate novel drug targets or to study the underlying causes of disease.
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Application note: Screening for optimal association and dissociation rates of ligands using a live cell binding assay
Potential drugs not only need to bind to their targets, they also need to remain bound for a specific amount of time in order to work efficiently.
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Expert view: Critical consumables: meeting the need for a steady supply of microplates
In a time when rapid screening and fast-paced drug development are necessary for fighting illness and disease, having a robust supply of high-quality, fit-for-purpose consumables is critical.
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Screening In-Depth Focus 2020
Included in this in-depth focus are articles on how high-throughput screening can be used to identify lead compounds, using chemoinformatics as a map to guide drug discovery and a novel in vitro model to screen potential treatments for non-alcoholic fatty liver disease (NAFLD).
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ebook: How to start your own lab
Learn practical tips from eight Principal Investigators about how to start your own lab.
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Blood test could identify those most at risk from COVID-19
Collaborative research has revealed two hallmarks of COVID-19 infection associated with more severe symptoms that can be identified by a blood test.
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Can a computer help us find a treatment for COVID-19?
Researchers are utilising computers to aid in their investigations into a COVID-19 treatment. Here, we highlight three studies using simulations, calculations and AI to identify a drug to combat the coronavirus.
