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“Off-the-shelf” immunotherapies for cancer
In this article, Drug Target Review's Victoria Rees explores a new method that could enable powerful immune cells to be produced in large quantities to treat a range of cancers.
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T cells
news
Rheumatoid arthritis discovery may lead to novel inflammation blockers
A new study links tumour necrosis factor seen in rheumatoid arthritis with T cell dysfunction, potentially leading to new therapies.
news
Replication proteins a potential new target for COVID-19 vaccines
A new study claims that future COVID-19 vaccines should activate T cells to attack infected cells expressing replication proteins.
podcasts
Episode 3 – Cell & gene therapy with Dr Sam Wadsworth, Ultragenyx Pharmaceutical & Dr Eric Ostertag, Poseida Therapeutics
Tune in to this podcast to learn about AAV vectors for gene therapy delivery and engineering CAR T cells against solid tumours.
video
Engineering better CAR T cells with Professor Ann Ager, Cardiff University
Watch this exclusive interview with Professor Ann Ager, Cardiff University, to discover how CAR T cells could be targeted against solid tumours.
news
Novel strategy successfully suppresses HIV infection in mice
A new method, called synapse for T-cell activation (synTac), can attack HIV-infected T cells and may be a new cure for HIV and other diseases.
article
High-throughput 3D cell migration assays in organ-on-a-chip technologies
Organ-on-a-chip models can provide an alternative to cell cultures, animal models and traditional assays. In this article, Dr Désirée Goubert, Thomas Olivier, Luuk de Haan and Dr Lenie van den Broek explore the advantages of organ-on-a-chip technologies and how they can enable the in vitro study of three-dimensional (3D) cell migration in…
news
Antidepressants inhibit growth of pancreatic and colon cancers in mice
Scientists have discovered that approved antidepressant drugs cause immune cells to recognise and eliminate tumour cells in mouse models.
news
New AI method could aid in development of T cell-based cancer therapies
An artificial intelligence technique can identify which neoantigens are recognised by the immune system, possibly improving cancer prognosis and treatment.
news
Lymph node-targeted vaccine elicits COVID-19 protection in vivo
Elicio Therapeutics’ lymph node-targeting vaccine displayed cellular and humoral immunity to SARS-CoV-2 in a pre-clinical study.
news
Novel tool can estimate number of T cells in cancer tumours
Researchers have developed a new method that can rapidly count the number of T cells in a tumour, helping to predict patient response to therapies.
news
Stem-like T cells could improve immunotherapy treatments
Targeting stem-like T cells within certain lymph nodes could improve the number of cancer patients that respond to immunotherapy treatments.
news
RN7SL1 RNA shown to activate T cells to fight against cancer
A new study found that the RNA RN7SL1 can activate T cells to seek out cancer cells, potentially improving cellular treatments.
news
Immune cell changes detected in Waldenstrom macroglobulinemia (WM)
A new study has found mutations originating in blood progenitor cells, possibly leading to Waldenstrom macroglobulinemia (WM) therapies.
news
Scientists develop novel strategy for tuberculosis vaccine
A research team have created a new strategy for developing an effective vaccine against a widespread form of tuberculosis.
