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Therapeutic peptide developed for triple-negative breast cancer
Scientists demonstrate how disrupting the Cx26 molecular complex in triple-negative breast cancer cells slowed tumour growth.
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Triple-negative breast cancer
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Transforming cancer treatment for greatest impact
In this Q&A, Dr Lev Becker, Associate Professor, University of Chicago and Cofounder of Onchilles Pharma, reveals how his company is directing research into neutrophil biology to the advantage of cancer patients that need it most.
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Highlights from PEGS Europe’s Protein & Antibody Engineering Summit
Drug Target Review’s Ria Kakkad recently travelled to Barcelona to attend PEGS Europe’s Protein and Antibody Engineering Summit. In this article, she shares her highlights from the event.
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Researchers find CD39 inhibition could be an effective strategy for immunotherapy
Scientists have discovered adenosine could inhibit CD39, a molecule that suppresses the immune system.
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Scientists have identified novel molecular biomarkers in cells that spread triple-negative breast cancer
The researchers identified key molecular differences between triple-negative breast cancer cells that cling to an initial tumour and those that venture off to form distant tumours.
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Scientists discover new molecule that kills hard-to-treat cancers
Scientists have synthesised a new molecule that could kill a broad spectrum of hard-to-treat cancers, including triple-negative breast cancer, by exploiting a weakness in cells not previously targeted by other drugs.
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Biodegradable gel boosts immune system’s attack on several cancers in mice
A new biodegradable gel can release drugs and special antibodies that simultaneously deplete macrophages from the surgical site and activate T cells.
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Researchers create triple-negative breast cancer organoids
Scientists have opened a path towards triple-negative breast cancer treatment, by creating organoids from tumour samples.
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Pre-clinical study shows significant increase in effectiveness of breast cancer immunotherapy
Scientists have discovered the essential role of a ligand-dependent corepressor to potentially enable cancer cells to present tumour antigens on their surfaces.
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Improved way to generate breast tumour models
Researchers have developed a new way to generate breast tumour models faster, more reliably and with less immune variability than existing models.
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Study shows how novel drug screen can personalise cancer therapy
A screening method called dynamic BH3 profiling can identify potentially effective combinations of existing drugs for personalised cancer therapy, research has shown.
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Small molecule screens reveal new class of anticancer compounds
Two screening techniques were used by researchers to find anticancer compounds that target the aryl hydrocarbon receptor.
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Sanguinarine shows promise against triple-negative breast cancer
A new study in cell cultures has shown that the sanguinarine plant compound could be used to treat people with triple-negative breast cancer.
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ProAgio drug shows success against solid tumours in mice
Studies in mice have shown that the drug ProAgio is effective at treating pancreatic cancer and triple-negative breast cancer.
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Developing an effective vaccine for breast cancer
This article summarises the development and testing of a novel vaccine that could be personalised for the treatment of immunotherapy-resistant cancers, such as triple-negative breast cancer (TNBC).