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Mucin 6 gene indicates predisposition to late-onset Alzheimer’s
Scientists have idenified that variation in a gene called Mucin 6 appears to indicate a tendency for acquiring Alzheimer’s disease.
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Disease Research
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Inflammatory regulatory protein identified by researchers
A study has discovered that the PKM2 protein plays a role in regulating immune cells and blocking this could be a potential treatment for inflammatory diseases.
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Better HIV, lupus and hep C treatments possible with malaria discovery
A new discovery on how the immune system responds to malaria infection could lead to better treatments for hepatitis C, HIV and lupus.
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New molecular drivers of Parkinson’s disease uncovered
Molecular drivers of Parkinson's disease have been revealed by scientists who also determined how they impact the functions of genes involved in the condition and the results may point to potential new treatments.
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ELRIG Drug Discovery 2019: looking back to the future
On 5-6 November, ACC Liverpool hosted the ELRIG Drug Discovery event, which allowed R&D professionals to come together and discuss the latest industry developments.
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Researchers identify antibody that could treat pulmonary arterial hypertension
A study has revealed a new antibody that reverses the effects of pulmonary arterial hypertension in rodents and cell models.
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Dysfunctional B cells found to contribute to age-related metabolic disease
A study has shown that a group of cells called adipose B cells can become dysfunctional with age, causing metabolic conditions such as diabetes, which has provided a drug target.
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Phage therapy shows potential to treat alcoholic liver disease
Researchers have discovered that patients with alcoholic hepatitis had high numbers of a destructive gut bacterium and they were able to use a cocktail of phages to target and kill the bacteria, eradicating the disease.
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Potential target found for tuberous sclerosis complex
A study on tuberous sclerosis complex has expanded the knowledge of the formation of this disease and how it can be targeted at the molecular level.
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Potential treatment path shown for subtype of Charcot-Marie-Tooth disease
A new study could pave the way for developing a viable therapy for Charcot-Marie-Tooth patients affected by TyrRS mutations.
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MaveDB: database to aid research into genetic causes of disease
Researchers in Australia and the US have launched the first open-source database detailing genetic variants that impact human health and disease.
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Key mechanism behind insulin release discovered by researchers
Researchers have identified a specific receptor that is critical for the release of insulin and provides a target for diabetes and obesity.
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RhoA protein function identified in nerve cell development
A recent study has revealed new findings about nerve cell development that could help to facilitate future treatment options for spinal cord injuries.
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Parkinson’s inhibitor enzyme presents natural therapeutic opportunity
Researchers have discovered an enzyme that blocks a genetic pathway that causes Parkinson’s, which could be used as a treatment in the future.
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Kinase identified as potential target for heart failure treatment
A new study has shown that restoring the amount of the kinase, HIPK2, in a kinase-depleted mouse model rescued it from heart failure and identifies HIPK2 as a novel regulator of heart failure progression.
