Chemokines work undercover as drivers of autoimmune disease
New research has uncovered a hitherto unknown mechanism whereby chemokines form DNA-bound nanoparticles that play a key role in autoimmune disorders.
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A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
New research has uncovered a hitherto unknown mechanism whereby chemokines form DNA-bound nanoparticles that play a key role in autoimmune disorders.
Scientists generated kidney organoids and used them to identify potential drugs to treat autosomal dominant polycystic kidney disease.
A new insight into the way the EGF receptor sends signals into cells could help researchers design new cancer drugs that target this protein.
For the first time, researchers have tested a molecule that combines three distinct technologies against glioblastoma, the most aggressive type of brain cancer.
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When the researchers increased the mitochondrial content with an inhibitor, the cancer cells responded to the treatment.
Scientists have developed a technology that can improve targeting specific organs and tissue types in gene therapy.
Researchers have found blood proteins that cause migraines and have a shared link with Alzheimer’s disease that could potentially be prevented by repurposing existing therapeutics.
Researchers have developed a novel method for enhancing CAR T therapy through a drug combination and cellular engineering that improves the strength and durability of the tumour-killing effect of a CAR T directed against AML.
In a new study, researchers have shared the identification of a new potential target for CAR T cells that inhibits growth in lung and ovarian tumours.
Researchers have shown that gene therapy using a single-dose injection of a virus carrying the ‘good’ gene could possibly be used to cure growth-hormone resistant dwarfism.
Scientists have engineered a new class of material which is able to both withstand the harsh acidic conditions of the stomach and then dissolve predictably in the comparatively gentle environment of the small intestine.
Scientists have gained new insights into the way G protein-coupled receptors operate, a step toward the development of improved drugs with fewer side effects.
Researchers have found new ways to artificially induce mRNA to respond in ways that could eventually lead to therapeutic outcomes.
Researchers defined 11 subsets of cells found in the oesophagus of mice. These findings could potentially help clinicians diagnose or treat certain types of cancer.