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T cells could work as therapy for IBD in children, finds study
Researchers have found that a type of T cell, called a Tr1 cell, could work as a therapeutic strategy for inflammatory bowel disease in children.
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Targets In-Depth Focus 2019
The articles in this In-Depth Focus explore a novel technique for studying protein aggregation in Alzheimer's research and explain how to maximise the potential of mass spectrometry.
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Structure of key pneumonia virus enzyme uncovered
Scientists have used cryo-electron microscopy to clarify the structure of one of the key components of RSV and HMPV, which could lead to new therapies for the viruses.
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Activating bone stem cells has potential therapeutic applications
A study has demonstrated that activating bone periosteal stem cells leads to increased bone healing in mice, presenting a potential therapeutic strategy.
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Drug Target Review – Issue 4 2019
This issue includes a discussion on the future of high-throughput screening through collaboration, an analysis of mass spectrometry as a structural biology tool and an exploration of the challenges of hit-to-lead when researching tropical diseases. Also in the issue are articles on immuno-oncology and assays.
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New class of drugs with potential to fight leukaemia and lymphoma discovered
PROTAC drugs that safely and effectively target leukaemia and lymphoma cells have been developed by researchers.
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Mouse model for prostate cancer bone metastasis developed
Researchers have developed a cell line that allows the mechanisms of prostate cancer bone metastasis to be studied in immunocompetent mice.
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Method to coax immune system into selecting HIV antibodies developed
Immunogens can be used to coax the immune system into producing broadly neutralising antibodies to fight a HIV infection, making a vaccine against the condition more likely, say researchers.
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Newly engineered peptide shows long-acting efficacy against HIV
Researchers have developed a novel peptide with a prolonged half-life that has demonstrated success in rhesus monkeys and mice for inhibiting HIV infections.
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New protein function could be key to treatment of drug addiction
Scientists have revealed new findings about the neural circuit involved in the reward stimulus, which plays a major role in drug dependence and psychological disorders.
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New generation of CAR T cells developed
Researchers have reprogrammed CAR T cells to prevent them becoming exhausted after prolonged activity, presenting a possible new therapy for solid tumours.
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Progression, trends and industry leaders in HIV and AIDS research
HIV is a disease still common in sub-Saharan Africa despite global research since 1982. This article delves into the trends, opportunities and key players in HIV research, exploring future possibilities for treating the disease.
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Two new retinal pigment epithelial cell models developed
Researchers have created two new cellular models that can be used in the study of ocular diseases and drug testing.
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Common signalling pathway across cancer and diabetes discovered by researchers
Researchers have found that the TRAP-alpha insulin biosynthesis pathway is essential in both cancer and diabetes, with a common primordial ancestor discovered in C. elegans.
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New screening method identifies potential compounds to combat cancer
The new screening technique may enable development of novel combination-immunotherapy regimens against cancers and persistent infections.
