A research team has found that blocking a particular kinase in a mouse model of arrhythmogenic cardiomyopathy led to improved survival rates.
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Researchers have found that inhibiting a kinase in mice leads to the death of prostate cancer cells, providing a potential therapeutic target.
Salk scientists discover a pair of enzymes that drive non-small-cell lung cancer by promoting inflammation which could inform the development of new therapies.
Breakthrough research has uncovered an unexpected mechanism that underlies cardiomyopathy in DMD...
Researchers in Spain have identified a means of classifying patients with the most aggressive form of breast cancer - triple negative breast cancer; providing meaningful prognosis for the first time.
Physiologically relevant screening models have become increasingly important in assay development and the screening of drug candidates.
A study has shown how the elimination of the c-Raf kinase by genetic manipulation causes the regression of Kras oncogene-driven advanced lung tumours...
A study has identified the genes involved in the latent asymptomatic state of breast cancer metastases...
Scientists have successfully blocked the powerful call of two types of aggressive cancer – glioblastoma and breast cancer – in laboratory models; with evidence that inhibiting the chemical 20-HETE halts tumour growth.
A team of researchers from the University of Liverpool and AstraZeneca has made an important contribution to our understanding of cancer cell regulation, holding promise for improved future cancer treatment.
The ATR protein has been imaged at ‘near-atomic resolution’, providing greater insight into its activation in DNA repair.
Are selective, brain-penetrant inhibitors of LRRK2 an answer?