A range of imaging and computational techniques were used by researchers to discover the structure of the PH domain of PLEKHA7.
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Jim Shanahan from SynDevRx explains why metabo-oncology treatment modalities could be the answer to a rise in metabolic disorders and cancers.
A new cancer-killing virus called CF33 has shown success in pre-clinical trials, helping the immune system to eradicate tumours.
A study has shown that two products of bacterial bile metabolism boost the conversion of precursor T cells into peripheral Tregs, which suppress chronic inflammation in the colon.
A study has shown that type II kinase inhibitors targeting CDK8 alone are ineffective because mutations leave them inactive, suggesting future therapies should target CDK8 in complex.
A team of scientists in the United States has successfully used a drug, which blocks AHR receptors, to prevent and treat obesity in mice. Their findings have spurred further research into the receptors’ association with diet and the gut microbiome.
Research indicates that activation of the RICTOR/mTORC2 pathway advances cancer metastasis and suggests that inhibiting this signalling may make chemotherapy more effective against colon cancer.
Copper oxide nanoparticles have successfully killed tumour cells in mice and when combined with immunotherapy, could work as a vaccine for cancer.
A new process for producing organoids allows researchers to explore intestinal epithelium in isolation and could allow for the development of improved targeted treatments of diseases.
New research has categorised hundreds of cancers based on their common protein mutations, highlighting cell components and tumour microenvironments as possible new therapy targets.
A study has demonstrated how mutations in early colon cancer prevail and grow into malignancies, using fluorescent imaging.
A new study has shown that proteins derived from the oncogene, KRAS, can transfer between colon cancer cells.
A new study shows that the activity of p38 is important in MSCs, which can localise around blood vessels.
A new study analysing both the entire set of genes and all the proteins produced by colon cancer tissues has revealed a more comprehensive view of the tumour.
Researchers have pinpointed a set of enzymes involved in tumor growth that could be targeted to prevent or treat colon cancer...