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Application note: See what’s really in your formulation with backgrounded membrane imaging
Backgrounded Membrane Imaging (BMI), used by the HORIZON® particle analysis system, performs measurements of subvisible protein aggregates.
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Discovering how drugs combat HIV and why resistance can occur
A group of researchers, led by Professor Zucai Suo, have revealed the mode of action of two HIV drugs and identified how resistance can develop, which they say could lead to improved drug design in the future.
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Novel label-free method enables imaging of metabolites
A label-free imaging technology has been developed by researchers, allowing them to investigate biomolecules such as metabolites, aiding in the study of drugs.
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Influenza B M2 proton channel structure resolved by researchers
Research into the M2 proton channel of influenza B has revealed its structure, which the team hope can aid in the development of targeted therapeutics to block the channel and treat the condition.
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Application note: Low volume, high-throughput subvisible AAV aggregate analysis with Horizon
Are you missing the bigger picture with your AAV analytics? Subvisible particle analysis should not require millilitres of precious sample.
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Imaging technique reveals how HIV drugs bind to viral structure
A new study has shown in three dimensions how drugs bind to HIV, which could be used to improve the design of drugs or develop novel therapies.
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Researchers suggest IMPDH enzyme could be used to target sleeping sickness
Research into drug targets for sleeping sickness parasite T. brucei has characterised the inosine-5'-monophosphate dehydrogenase (IMPDH) enzyme, providing a possible novel avenue for therapies.
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Diabetes-related proteins examined for the first time at high resolution
A key receptor has been examined for the first time at high resolution which could lead to better treatments for conditions such as type 2 diabetes.
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New capillary model could provide new therapies for malaria
Researchers have produced a capillary model which allows investigation of the dynamics of blood flow obstruction in real scale and could be used to test new therapies for P. falciparum malaria.
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Lower levels of SV2A protein identified as drug target for schizophrenia
Using brain scans, a study has shown that schizophrenia patients have lower levels of the protein SV2A in their brains which presents a drug target.
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Deep learning network used to model protein complexes
A new study has developed a deep learning approach that analyses protein interactions, which could improve the design of drugs in the future.
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New virus surface characterisation technique developed
Researchers have demonstrated the success of a new single-particle method of studying the surface of viruses, which could improve vaccine purification and the development of gene therapies.
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Researchers image C. diff toxins to aid in drug design
A new study has used several imaging techniques to characterise C. diff toxins, which could help to design drugs to combat infections from the bacteria.
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Novel spectrometer technology can analyse molecular composition of biological samples
A new spectrometer laser system has been developed by researchers in Germany, which can detect specific compounds in biological samples.
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First images of an ‘upgraded’ CRISPR tool captured
Researchers have utilised cryo-electron microscopy and used the images they captured with an electron microscope to generate atomic resolution models of the INTEGRATE system.
