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High-throughput screening assay developed to discover antimalarials
A new assay has been developed to screen for small molecule inhibitors of the Rh5 protein, which is essential for malaria parasite survival.
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Walter and Eliza Hall Institute
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Single-cell approach generates RNA atlas of breast cancer tissue
Researchers have measured the gene expression of healthy and cancerous single cells from breast tissue, creating an 'RNA atlas'.
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Nanobody cocktail shown to block SARS-CoV-2 infection in mouse models
Researchers have used cryo-EM to show that a new nanobody cocktail can bind to the S protein of SARS-CoV-2, neutralising the coronavirus.
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New cancer treatment regimens could be identified with novel technology
A new technology called mass cytometry, or CyTOF, is providing new insights into a range of key proteins in blood cancer cells.
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New drug discovery centre with screening capabilities opens in Australia
The National Drug Discovery Centre (NDDC) has opened in Australia, with support from the government to subsidise the screening of medicinal compounds.
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Novel compound to kill malaria parasites developed by researchers
A collaborative team has developed a compound called WM382, which targets two crucial enzymes in the malaria parasite, effectively killing it.
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Natural killer cells identified as source of inflammation in rheumatoid arthritis
A study has shown that natural killer cells are linked to the protein GM-CSF, which causes inflammation, indicating a new target for rheumatoid arthritis.
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Better HIV, lupus and hep C treatments possible with malaria discovery
A new discovery on how the immune system responds to malaria infection could lead to better treatments for hepatitis C, HIV and lupus.
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MaveDB: database to aid research into genetic causes of disease
Researchers in Australia and the US have launched the first open-source database detailing genetic variants that impact human health and disease.
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‘Ubiquitin clipping’ proteomics technique could be used as novel treatment
A new technique called ‘ubiquitin clipping’ has been created which could aid proteomics research and the development of new drugs for ubiquitination.
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Anti-viral immune discovery could lead to improved vaccines
A molecular switch that impacts immune responses to viral infections has been identified which could lead to better strategies to develop vaccines.
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Scientists pinpoint mechanism by which mutant p53 protein promotes cancer
Scientists in Australia have discovered how the most important gene in preventing cancer, TP53, is hampered in its tumour-fighting efforts by mutant p53 proteins.
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3D image of insulin and its receptor revealed
After combining over 700,000 2D images, researchers have finally been able to build a 3D image of how insulin binds to its receptor...
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Human immune ‘trigger’ map paves way for better treatments
A discovery about how human cells are 'triggered' to undergo an inflammatory type of cell death could have implications for treating cancer, stroke and tissue injury, and immune disorders...
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DNA gets away: Scientists catch the rogue molecule that can trigger autoimmunity
A research team has discovered the process - and filmed the actual moment - that can change the body’s response to a dying cell.