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High-throughput screening reveals new compound to maintain lung health
Researchers have screened 20,000 molecules to discover a potent compound with low toxicity that restores the balance of healthy stem cells in the lungs of mice.
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Researchers map vital atomic-scale protein on COVID-19
Using cryogenic electron microscopy, a team has mapped the Spike protein on COVID-19, which could be used in the development of vaccines.
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Researchers gain new insight into LRRK2 – a potential cause of Parkinson’s
Scientists in the US have applied a novel technique to finally unravel a particular kinase enzyme that is associated with familial Parkinson’s disease; providing a clearer potential therapeutic target.
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Receptor protein activity could prevent neuropathy for chemotherapy patients
A team of researchers in Singapore has studied the activity of a receptor protein to identify whether it’s a key player in the development of neuropathy for patients undergoing chemotherapy.
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Novel molecules to adjust the circadian rhythm
A collaborative team of researchers has discovered two molecules that target the melatonin receptor, responsible for regulating the circadian rhythm. This article delves into their study and its therapeutic relevance for the body clock.
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Targeting CD36 with antibody inhibits Treg tumour protection in mice
Researchers have discovered that an antibody which targets the CD36 protein prevents Tregs from protecting tumours against immunotherapies in mouse models.
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Clusterin proteins’ cleanup mechanism is identified
The body’s means of maintaining health are diverse and plentiful, and now researchers in Japan have identified another metaphorical string to its bow: the ability to prevent cell damage using cleanup clusterin proteins that channel damaged proteins for disposal.
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Novel technique creates complex synthetic drug molecules
A new method has been developed by researchers to create synthetic molecules which replicate natural structures and have potential medicinal uses.
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Myc gene linked to alternative splicing changes in several cancers
A collaboration of academic institutions in the United States has identified a gene that is linked to alternative splicing changes that occur in several cancers.
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Discovering how drugs combat HIV and why resistance can occur
A group of researchers, led by Professor Zucai Suo, have revealed the mode of action of two HIV drugs and identified how resistance can develop, which they say could lead to improved drug design in the future.
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Artificial intelligence trained to find disease-related genes
Researchers have developed an artificial neural network using deep learning to identify genes that are related to disease.
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New variant of the GLA gene to be linked with Fabry cardiomyopathy
A study in Finland has found a strong connection between the A143T variant of the GLA gene and increased risk of Fabry cardiomyopathy, which affects the heart, kidneys and nervous system.
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Increasing NAD levels could improve quality of eggs, says research
A study has identified that infertility due to age-related defects in eggs could be improved by raising levels of NAD, presenting a possible novel fertility treatment.
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ELRIG and the British Pharmacological Society: why form a strategic alliance?
Here, the benefits of collaborating in drug discovery are explored through the strategic alliance between ELRIG and the British Pharmacological Society.
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Murine model for coeliac disease may lead to future therapies, say researchers
Using an innovative approach to create a model organism, scientists have translated human research into a murine model which they say more accurately reflects coeliac disease.
