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Myc gene linked to alternative splicing changes in several cancers
A collaboration of academic institutions in the United States has identified a gene that is linked to alternative splicing changes that occur in several cancers.
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Discovering how drugs combat HIV and why resistance can occur
A group of researchers, led by Professor Zucai Suo, have revealed the mode of action of two HIV drugs and identified how resistance can develop, which they say could lead to improved drug design in the future.
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Artificial intelligence trained to find disease-related genes
Researchers have developed an artificial neural network using deep learning to identify genes that are related to disease.
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New variant of the GLA gene to be linked with Fabry cardiomyopathy
A study in Finland has found a strong connection between the A143T variant of the GLA gene and increased risk of Fabry cardiomyopathy, which affects the heart, kidneys and nervous system.
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Increasing NAD levels could improve quality of eggs, says research
A study has identified that infertility due to age-related defects in eggs could be improved by raising levels of NAD, presenting a possible novel fertility treatment.
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ELRIG and the British Pharmacological Society: why form a strategic alliance?
Here, the benefits of collaborating in drug discovery are explored through the strategic alliance between ELRIG and the British Pharmacological Society.
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Murine model for coeliac disease may lead to future therapies, say researchers
Using an innovative approach to create a model organism, scientists have translated human research into a murine model which they say more accurately reflects coeliac disease.
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Using Ebola’s immune evasion mechanism to target glioblastoma
An innovative chimeric vaccine containing an Ebola gene that helps the virus evade the immune system has been used to selectively target and kill glioblastoma in mice.
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Carbon hydrogen functionalisation could provide new route for synthesising compounds
The carbon hydrogen functionalisation process could be used to make 3D scaffolds for pharmaceutical compounds, say researchers.
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Blood-brain-barrier modelled in 3D on precision chip
Researchers have engineered a chip which allows 3D modelling of the blood-brain-barrier and has provided insight into how astrocytes facilitate transport of molecules.
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ETV4 protein implicated in cancer-promoting oestrogen signalling
Research into gynaecological cancers has shown that removing the ETV4 protein from endometrial cancer cells reduces oestrogen signalling and subsequently tumour growth.
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Free radicals from immune cells cause salt-sensitive hypertension
A new study has found that in salt-sensitive hypertension, immune cells gather and release free radicals, damaging the kidneys.
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Gut organoid helped to define leaky gut and could aid in treatment development
Research has shown that leaky gut, the break down of gut lining junctions, could be targeted to reduce inflammation using metformin using an organoid model.
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Astrocytes could be harnessed to protect motor neurons in MND
Scientists using a new motor neuron disease (MND) model have shown astrocytes may protect neurons from toxic TDP-43 protein aggregates in the early stages of disease.
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The fate of cancer is all down to particular proteins
Scientists in Japan have identified an important protein that can impact the course of cancer and its fate in the human body.
