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Nuclear tracers help assess new drugs for neurodegenerative diseases

21 January 2019 | By Dr Zara Kassam (Drug Target Review)

New nuclear medicine tracers could help medical researchers find a cure for Alzheimer's and other neurodegenerative diseases.

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Application note: GABA_A Receptors

11 December 2018 | By SB Drug Discovery

SB Drug Discovery shows the validation of fluorescence and automated electrophysiology assays designed to assess agonists, antagonists and allosteric modulators of these receptors, culminating in a high-throughput electrophysiology assay suited to assessing multiple GABAA receptor subtypes on a single assay plate.

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Compounds in coffee may fight Parkinson’s

11 December 2018 | By Drug Target Review

Caffeine plus another compound in coffee beans' waxy coating may protect against brain degeneration...

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Depleting ErbB4 gene alleviates Schizophrenia symptoms in new mouse models

3 December 2018 | By Dr Zara Kassam (Drug Target Review)

Restoring brain cell receptors helps restore normal behaviour...

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MRI scans shows promise in predicting dementia

23 November 2018 | By Drug Target Review

Brain changes evident in scans before memory, cognitive decline...

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New information on the pathological mechanisms of Alzheimer’s disease

21 November 2018 | By Drug Target Review

Researchers have indicated that the accumulation of pathological tau triggers a safety valve mechanism in the otherwise well-regulated cell membranes...

Charles River Laboratories Continues Commitment to Oncology Drug Discovery

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Charles River Laboratories continues commitment to oncology drug discovery

16 November 2018 | By Charles River Laboratories

Team of oncology experts expand data in Tumor Model Compendium and present strong portfolio at industry conferences...

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Sensory neurons can be used to discover therapies for ALS

9 November 2018 | By Drug Target Review

New approach for testing for ALS may be useful to reverse debilitating disease...

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Brain activity pattern may be early sign of schizophrenia

8 November 2018 | By Drug Target Review

In a study that might enable earlier diagnosis, neuroscientists find abnormal brain connections that can predict the onset of psychotic episodes...

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Charles River to present collaborative methods at Neuroscience 2018

5 November 2018 | By Charles River Laboratories

Charles River Laboratories International, Inc. (NYSE: CRL) announced that its team of neuroscience drug discovery experts will present 26 scientific posters, both independently and collaboratively with clients, at Neuroscience 2018, the 48th annual meeting of the Society for Neuroscience (SfN)...

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Better drug delivery through the blood-brain barrier

19 October 2018 | By Iqra Farooq (Drug Target Review)

Drug delivery through the blood-brain barrier has shown to be difficult to overcome, but researchers may have discovered a method to overcome this issue...

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Laser-capture RNA seq technique connects Parkinson’s and psychiatric diseases

21 September 2018 | By Drug Target Review

A comprehensive study reveals an expanding universe of 'darkest of the dark matter' RNAs in dopamine-producing cells in our brains...

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New biomarker panel could accelerate autism diagnoses

17 September 2018 | By Drug Target Review

Researchers have identified a group of blood metabolites that could help detect some children with autism spectrum disorder (ASD)...

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Short protein fibres predict the onset and course of Huntington’s disease

6 September 2018 | By Drug Target Review

A research team has reported that short protein fibres precede the formation of larger deposits that accumulate in the brains of those affected by the incurable Huntington's disease...

Del Trezise, Head of Applications, BioAnalytics, Sartorius AG

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Expert view: New developments in real‑time live‑cell analysis

5 September 2018 | By Del Trezise

Live-cell analysis is now a well-established method that is part of the everyday cell biologist’s armoury for understanding cell biology. For over a decade, the functionality, throughput, and ease of use offered by real-time live-cell analysis has provided a platform for accurate and reproducible cell biology analysis in multiple biomedical…

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Neurosciences