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Targets In-Depth Focus 2019
The articles in this In-Depth Focus explore a novel technique for studying protein aggregation in Alzheimer's research and explain how to maximise the potential of mass spectrometry.
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Neurosciences
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Drug Target Review – Issue 4 2019
This issue includes a discussion on the future of high-throughput screening through collaboration, an analysis of mass spectrometry as a structural biology tool and an exploration of the challenges of hit-to-lead when researching tropical diseases. Also in the issue are articles on immuno-oncology and assays.
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New protein function could be key to treatment of drug addiction
Scientists have revealed new findings about the neural circuit involved in the reward stimulus, which plays a major role in drug dependence and psychological disorders.
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Vasomotion revealed as potential strategy to treat Alzheimer’s
A study has demonstrated that inducing brain vessel pulsations helps to clear substances from the brains of mice, so could be used to stop amyloid-β build up in the development of Alzheimer’s.
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Direct link shown between inflammasome activation and Alzheimer’s
A new study has demonstrated that NLRP3 inflammasome directly drives tau pathology in neurodegenerative diseases and Alzheimer's disease.
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Researchers find mutation in CUL3 gene responsible for autism
Scientists have shown that the mutated CUL3 gene, which is involved in the cell’s clearance of proteins, plays a role in the development of autism and schizophrenia in mice.
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New molecular drivers of Parkinson’s disease uncovered
Molecular drivers of Parkinson's disease have been revealed by scientists who also determined how they impact the functions of genes involved in the condition and the results may point to potential new treatments.
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ELRIG Drug Discovery 2019: looking back to the future
On 5-6 November, ACC Liverpool hosted the ELRIG Drug Discovery event, which allowed R&D professionals to come together and discuss the latest industry developments.
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Self-cannibalising mitochondria discovery may lead to ALS treatment target
A new phenomenon in the brain that could explain the development of early stages of neurodegeneration has been discovered which could lead to a future target for drug therapies for ALS.
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Parkinson’s inhibitor enzyme presents natural therapeutic opportunity
Researchers have discovered an enzyme that blocks a genetic pathway that causes Parkinson’s, which could be used as a treatment in the future.
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First detailed 3D image of astrocytes produced by researchers
Researchers have compiled images to create the first detailed 3D models of astrocytes, which could be used in the development of therapeutics to aid their function.
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Intervening tau accumulation could halt progression of Alzheimer’s
A group of researchers has found that tau misfolding is not harmful in itself, but instead the cellular processes its affects kills neurons.
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New discovery leads to greater understanding of Alzheimer’s disease
A new study has linked an inflammatory protein to impaired memory mechanisms which could lead towards finding a more effective treatment for Alzheimer's.
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Novel therapeutic strategy reverses autism symptoms in mice
Researchers have discovered a pathway that causes behavioural abnormalities and other hallmarks of autism; they also revealed how to silence this and reverse the symptoms in mice.
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Study finds astrocytes critical in progression of Huntington’s disease
The new research shows that astrocytes contribute to Huntington’s disease symptoms, but suppressing a mutation stops the disease from progressing.
