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Expert view: Promising methods in kinase screening
Kinase-mediated phosphorylation is a control point for nearly all activity within a cell, making kinases important in many diseases.
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Screening
Medical screening is a strategy used to identify the possible presence of an as-yet-undiagnosed disease in individuals without signs or symptoms.
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Hit-To-Lead In-Depth Focus 2019
This in-depth focus features articles on identifying new leads for neglected tropical diseases and how to develop novel peptide hits into lead compounds.
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Screening In-Depth Focus 2019
In this In-Depth Focus are articles investigating how CROs can help to drive innovation and how CRISPR technologies could be used for drug screening purposes.
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Drug Target Review – Issue 4 2019
This issue includes a discussion on the future of high-throughput screening through collaboration, an analysis of mass spectrometry as a structural biology tool and an exploration of the challenges of hit-to-lead when researching tropical diseases. Also in the issue are articles on immuno-oncology and assays.
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Root of childhood kidney cancer discovered
The earliest genetic root of Wilms' tumour has been discovered, which could not only lead to improved treatments but to one day being able to screen for cancers like this before tumours develop.
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The Olympus scanR high-content screening station rapidly acquires quantitative data from cell-based assays
Self-learning microscopy opens new horizons in high-content analysis and advances phenotypic screening.
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Two new retinal pigment epithelial cell models developed
Researchers have created two new cellular models that can be used in the study of ocular diseases and drug testing.
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New screening method identifies potential compounds to combat cancer
The new screening technique may enable development of novel combination-immunotherapy regimens against cancers and persistent infections.
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Researchers must not rely on generic online searches for chemical probes, study finds
The ICR has revealed that during drug discovery, researchers should not use general search engines and vendor catalogue information to decide on their use of chemical probes.
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Animal model market set to grow to $24bn by 2025
New research has found that the animal model market for disease research and therapeutic testing will exhibit strong growth.
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Application note: Measure cancer cell viability using a homogeneous, stable luminescence assay
Learn how to screen for cell viability with the CellTiter-Glo assay on the SpectraMax® iD5 Multi-Mode Microplate Reader.
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Fruit fly model to study mitochondrial diseases developed
Researchers have created ‘three-parent flies' which can be used as a model to study mitochondrial diseases and screen potential drug compounds.
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Human heart-in-a-jar model to be developed
Researchers will create the first human heart-in-a-jar to study heart failure, identify new therapeutic targets and test novel treatments.
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Fungi library could aid in the search for medical drugs
A library of products derived from more than 10,000 fungi has been established which could lead to the discovery of new drugs.
whitepaper
Application note: A Simoa™ Bridging Assay for Anti Drug Antibody Detection
Therapeutic drugs based on biological materials (antibodies, hormones, cytokines, enzymes, fusion proteins) may have the ability to elicit an immune response in the host.
