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Bile acids acting as inflammation regulators may protect against IBD
Research has found that bile acids, converted by gut microbes, act as inflammatory regulators in IBD by modulating the differentiation of T cells in the gut.
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Crohn’s disease
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Potential treatment target identified for Crohn’s disease
Researchers have identified a pathway in the immune system activated in Crohn's disease which could lead to investigating new treatments.
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Research identifies cells which contribute to inflammatory diseases
A new study has shown that there are two populations of cells in the gut which leads to drug development potential.
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Inflammation inhibitor could be used to treat sepsis
An inhibitor that stops the action of OGG1 signals, could potentially be used as a treatment for life-threatening Acute Respiratory Distress Syndrome...
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miR-31 may help target treatments for Crohn’s patients
Researchers have pinpointed a single molecule - microRNA-31 (miR-31) - the levels of which predict whether a patient has subtype 1 or subtype 2 of Crohn's disease...
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Searching for targeted treatments for inflammatory diseases
Scientists have identified identified key regulators that are essential for controlling the inflammatory response in Crohn’s disease and multiple sclerosis.
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Faulty gene could be responsible for some Crohn’s disease cases
Interaction between MDR1 gene and TH17 immune cells in the ileum could hold the key to Crohn's disease in some instances.
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Engineering the gut microbiome may help treat Crohn’s disease
Researchers have singled out a bacterial enzyme behind an imbalance in the gut microbiome linked to Crohn's disease...
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Researchers produce the first draft cell atlas of the small intestine
By surveying gene expression, researchers have created a reference atlas for understanding the biology of inflammatory bowel disease and food allergies, among other conditions...
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CRISPR gives new insight into autoimmune disorders
Researchers have used a modified version of the gene-editing technique CRISPR in search for gene activators...
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Biologic treatments for inflammatory bowel disease help heal the intestine
Although anti-inflammatory treatments are quite effective at reducing symptoms in patients with Crohn's disease and ulcerative colitis, the mucosal lining of the intestine often remains ulcerated, and many patients still ultimately require surgery.
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Discovery of novel targets and therapeutics for Crohn’s disease
7 January 2016 | By Nicholas Jackson
Enterome announces collaboration with Johnson & Johnson Innovation focused on the discovery of novel targets and therapeutics for Crohn’s disease...
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ReproCELL acquires Scottish life sciences company Biopta
25 November 2015 | By Victoria White
The transaction, expected to complete next month, is aimed at strengthening ReproCELL’s pharmaceutical industry-targeted drug discovery services...
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Boehringer Ingelheim pledges EUR 11 billion to R&D
11 November 2015 | By Victoria White
Of the total investment, EUR 5 billion will go to preclinical R&D with EUR 1.5 billion thereof planned for collaborations with external partners...
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Boehringer Ingelheim announces IBD research collaborations
10 November 2015 | By Victoria White
The collaborations aim to identify and validate potential new therapeutic targets as well as identify biomarkers...