Expert view: Promising methods in kinase screening
Kinase-mediated phosphorylation is a control point for nearly all activity within a cell, making kinases important in many diseases.
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Kinase-mediated phosphorylation is a control point for nearly all activity within a cell, making kinases important in many diseases.
In this In-Depth Focus are articles investigating how CROs can help to drive innovation and how CRISPR technologies could be used for drug screening purposes.
This issue includes a discussion on the future of high-throughput screening through collaboration, an analysis of mass spectrometry as a structural biology tool and an exploration of the challenges of hit-to-lead when researching tropical diseases. Also in the issue are articles on immuno-oncology and assays.
The earliest genetic root of Wilms' tumour has been discovered, which could not only lead to improved treatments but to one day being able to screen for cancers like this before tumours develop.
Self-learning microscopy opens new horizons in high-content analysis and advances phenotypic screening.
Researchers have created two new cellular models that can be used in the study of ocular diseases and drug testing.
The new screening technique may enable development of novel combination-immunotherapy regimens against cancers and persistent infections.
The ICR has revealed that during drug discovery, researchers should not use general search engines and vendor catalogue information to decide on their use of chemical probes.
New research has found that the animal model market for disease research and therapeutic testing will exhibit strong growth.
Learn how to screen for cell viability with the CellTiter-Glo assay on the SpectraMax® iD5 Multi-Mode Microplate Reader.
Researchers have created ‘three-parent flies' which can be used as a model to study mitochondrial diseases and screen potential drug compounds.
Researchers will create the first human heart-in-a-jar to study heart failure, identify new therapeutic targets and test novel treatments.
A library of products derived from more than 10,000 fungi has been established which could lead to the discovery of new drugs.
Therapeutic drugs based on biological materials (antibodies, hormones, cytokines, enzymes, fusion proteins) may have the ability to elicit an immune response in the host.
A compound that has antimicrobial properties has been found by researchers, which could be used to combat drug-resistant infections.