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Computational method used to quantify tRNAs in any organism
Researchers have developed a new technique called mim-tRNAseq to measure, map and analyse tRNAs in cells, providing insight into disease.
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Amino Acids
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Synthetic peptides block atherosclerosis in pre-clinical studies
Researchers have synthesised peptides that function like a soluble chemokine receptor, blocking atherosclerosis in animal models.
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D-serine could protect against epileptic seizures
Scientist identified the mechanism through which temporal lobe epileptic seizures are sparked and that D-serine can interfere with this process, preventing seizures.
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Protease inhibitors could be highly effective against SARS-CoV-2
Researchers reveal the main protease (Mpro) of SARS-CoV-2 is highly sensitive to disruption, therefore Mpro inhibitors could be a potential COVID-19 therapeutic.
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Flow synthesis technology enables faster protein production
The novel protocol allows proteins over 100 amino acids long to be synthesised in hours and include amino acids that do not occur in the human proteome.
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Human enzymes could be driving COVID-19 evolution, suggest researchers
Post-infection genome editing could be the cause of mutations in the SARS-CoV-2 virus responsible for the COVID-19 pandemic, driving its evolution.
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Investigational drug kills pancreatic cells in mice by cutting off cysteine supply
Researchers have demonstrated that cysteinase, a new drug compound, can starve pancreatic cells of cysteine supply, causing ferroptosis.
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Artificial binding protein could be developed into a novel anti-viral or cancer therapy
Scientists have created an artificial protein able to recognise and bind cell surface carbohydrates with high affinity and selectivity.
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L-serine could be used to treat ALS, after promising results in primate study
Researchers have shown that, when treated with L-serine, a non-human primate model of ALS had fewer pathologies associated with the disease.
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3D tissue models of brain tumours created in brain-mimicking environment
A new platform has the potential to better understand what dictates the invasive behaviour of brain tumours.
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New method for developing medical imaging tracers discovered
A new medical imaging tracing method has been discovered by scientists which can better track drugs in the body.
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Anti-inflammatory bacterial protein discovered in zebrafish
An anti-inflammatory bacterial protein discovered in zebrafish could lead to the discovery of anti-inflammatory proteins within humans...
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Atg2 tethers pre-autophagosomal membranes to endoplasmic reticulum
Researchers at Tokyo University have investigated the role of the Atg2 protein in the process of autophagy to aid drug discovery into neurodegeneration...
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Elrig 2018: Drug discovery using small and large molecules
The Drug Target Review team are at Elrig Drug Discovery 2018 in the London ExCel...
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Double-bridged peptides bind any disease target
Researchers have developed a new peptide format that they call double-bridged peptides...